Breast Cancer Awareness Month

[MSimon]

http://en.wikipedia.org/wiki/Anandamide

A study published in 1998 shows that anandamide inhibits human breast cancer cell proliferation.[13]

13. De Petrocellis L et al. (July 1998). "The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8375–80. doi:10.1073/pnas.95.14.8375. PMC 20983. PMID 9653194.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC20983

http://www.ncbi.nlm.nih.gov/pubmed/9653194

The plant analog for anandamide is THC.

[paperburn1]

Druggies sheesh
This is from the author and discover
Three compounds that strongly resemble anandamide were found in dark chocolate by Daniele Piomelli and co-workers at the Neurosciences Institute in San Diego [Piomelli, 1996]. They also found compounds (N-acylethanolamines) that block the breakdown of anandamide. Piomelli speculates that part of the pleasure of chocolate comes from anandamide and the anandamide-preserving N-acylethanolamines. "We are talking about something much, much, much, much milder than a high", he says.

The Nature article has been used by some to equate the effects of chocolate and cannabis to bolster arguments about the legalization of marijuana. "It is not that simple," Piomelli says. The response to THC and to the chocolate anandamides are not at all the same, even if the concentrations could be made comparable.

[MSimon]

Druggies sheesh
This is from the author and discover
Three compounds that strongly resemble anandamide were found in dark chocolate by Daniele Piomelli and co-workers at the Neurosciences Institute in San Diego [Piomelli, 1996]. They also found compounds (N-acylethanolamines) that block the breakdown of anandamide. Piomelli speculates that part of the pleasure of chocolate comes from anandamide and the anandamide-preserving N-acylethanolamines. "We are talking about something much, much, much, much milder than a high", he says.

The Nature article has been used by some to equate the effects of chocolate and cannabis to bolster arguments about the legalization of marijuana. "It is not that simple," Piomelli says. The response to THC and to the chocolate anandamides are not at all the same, even if the concentrations could be made comparable.

Well that is true. The entourage effect comes into play with plant cannabinoids. And what do we know to be true? Plant cannabinoids have anti tumor properties according to the National Cancer Institute.

http://www.cancer.gov/cancertopics/pdq/ ... onal/page4

Antitumor Effects

One study in mice and rats suggested that cannabinoids may have a protective effect against the development of certain types of tumors.[3] During this 2-year study, groups of mice and rats were given various doses of THC by gavage. A dose-related decrease in the incidence of hepatic adenoma tumors and hepatocellular carcinoma (HCC) was observed in the mice. Decreased incidences of benign tumors (polyps and adenomas) in other organs (mammary gland, uterus, pituitary, testis, and pancreas) were also noted in the rats. In another study, delta-9-THC, delta-8-THC, and cannabinol were found to inhibit the growth of Lewis lung adenocarcinoma cells in vitro and in vivo .[4] In addition, other tumors have been shown to be sensitive to cannabinoid-induced growth inhibition.[5-8]

Cannabinoids may cause antitumor effects by various mechanisms, including induction of cell death, inhibition of cell growth, and inhibition of tumor angiogenesis invasion and metastasis.[9-12] Two reviews summarize the molecular mechanisms of action of cannabinoids as antitumor agents.[13,14] Cannabinoids appear to kill tumor cells but do not affect their nontransformed counterparts and may even protect them from cell death. These compounds have been shown to induce apoptosis in glioma cells in culture and induce regression of glioma tumors in mice and rats. Cannabinoids protect normal glial cells of astroglial and oligodendroglial lineages from apoptosis mediated by the CB1 receptor.[15]

Now here is where it gets really good in terms of the anandamide study above:

The effects of delta-9-THC and a synthetic agonist of the CB2 receptor were investigated in HCC.[16] Both agents reduced the viability of HCC cells in vitro and demonstrated antitumor effects in HCC subcutaneous xenografts in nude mice. The investigations documented that the anti-HCC effects are mediated by way of the CB2 receptor. Similar to findings in glioma cells, the cannabinoids were shown to trigger cell death through stimulation of an endoplasmic reticulum stress pathway that activates autophagy and promotes apoptosis. Other investigations have confirmed that CB1 and CB2 receptors may be potential targets in non-small cell lung carcinoma [17] and breast cancer.[18]

An in vitro study of the effect of CBD on programmed cell death in breast cancer cell lines found that CBD induced programmed cell death, independent of the CB1, CB2, or vanilloid receptors. CBD inhibited the survival of both estrogen receptor–positive and estrogen receptor–negative breast cancer cell lines, inducing apoptosis in a concentration-dependent manner while having little effect on nontumorigenic, mammary cells.[19]

Prohibitionists are really an evil lot. Not to mention ignorant. Now why don't we have in vivo studies? Other than anecdotes? Because the prohibition enforcers will not allow them. Lest people in general find out it is a cure for some cancers and maybe all of them. Word is getting out. And the prohibitionists will be a very reviled lot when the general population figures out that Mom didn't have to die from breast cancer. Junior's inoperable brain tumor didn't need to be a death sentence. That diabetes is an auto-immune disease treatable (in some - estimates are around 2/3rds) by cannabis.

Prohibitionists sheesh.

Cannabinoids regulate the immune system. Such regulation could be a preventive from death by cytokine storm (you know Ebola). But Prohibition prevents the research from going forward.

But Americans will be doing a little about that tomorrow. And every year we will do more until the evil of Prohibition is ended.

And a time will come when "druggies" are held in esteem and Prohibitionists are reviled. Not too far off I recon.

We have on record where you stand.

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But I do understand your essential problem. Your endocannabinoid production has declined since you were 25 or 30 and you are incapable of changing your world view,