Factor X have we finally found the fountain of Youth?

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kurt9
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Re: Factor X have we finally found the fountain of Youth?

Postby kurt9 » Sun Aug 11, 2019 2:25 am

That's the point. The epigenetic changes are clearly the cause of all of the aging based dysfunction. That's why if someone comes up with a workable cellular reprogramming protocol that both works and is safe, I will most certainly do it. In the meantime, there is mitochondrial related stuff as well as senolytics that I will do starting early next year.

If nuclear DNA really is a cause of aging, there's a fix for that in the form of a CRISPR therapy that is targeted specific to stem cells that was just developed by Harvard. I think it is also this same thing that George Church used to rejuvenate his lab rats a few months ago.

williatw
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Re: Factor X have we finally found the fountain of Youth?

Postby williatw » Sun Aug 11, 2019 2:58 am

kurt9 wrote:That's the point. The epigenetic changes are clearly the cause of all of the aging based dysfunction. That's why if someone comes up with a workable cellular reprogramming protocol that both works and is safe, I will most certainly do it. In the meantime, there is mitochondrial related stuff as well as senolytics that I will do starting early next year.


There could be the programmed "epigenetic changes" causing "aging based dysfunction" and also in addition accumulating damage as a result of simply living. Drinking, smoking, breathing polluted air, other contaminates in the environment from food/drink etc. Even if our repair mechanism(s) didn't degrade as a result of epigenetic changes there would still be cumulative damage from that. Merely the fact that we need oxygen to process our food generates free radicals that yes damage us over time even with repair mechanism functioning at the "youthful" level. I am not as ambitious (brave) as you are; my current regime is notable for Elysium Basis (recently) and Longevinex for many years; the later recently added Fisetin to it's ingredients list probably in too low a concentration. Very recently added Berberine to my mix as a substitute for Metformin requiring a prescription. Stem cell therapies are an interest of mine as well but haven't been bold enough (or rich enough) to take advantage of them yet. I have diagnosed arthritis in my left shoulder with accompanying bone spurs. Understand famously that Mel Gibson's then 92 yr old Dad received stem cell therapy for a host of issues with apparently (continuing) good results several years ago.

Host Michael Beattie discusses stem cell therapy using *human umbilical cord tissue-derived mesenchymal stem cells (hUCT-MSCs) at the Stem Cell Institute in Panama with renowned applied stem cell scientist and founder, Neil Riordan, Pa, PhD and acclaimed actor, director and producer Mel Gibson.

Dr. Riordan discusses the miraculous progress of a spinal cord injury patient and pilot whose doctors said that he would never walk again. He talks about where the stem cells come from, how they work and why they can treat so many seemingly different conditions. Dr. Riordan explains how umbilical cords, and subsequently, hUCT-MSCs used at the Stem Cell Institute are carefully selected using molecular screening. He also discusses why mesenchymal stem cells from umbilical cords function better than MSCs from adults, especially as they age or if they are suffering from a disease like multiple sclerosis. For example. MSCs from a newborn multiply exponentially compared to MSCs from an older adult.

Mel Gibson discusses his father’s miraculous recovery, literally from his deathbed after receiving hUCT-MSCs at the age of 92. He’s currently 99 and still going strong having been treated in Panama several times since then. Mel also discusses his personal experiences in Panama.


ADDENDUM; More details on Riordan's treatment regime and facility:


Stem Cells: Their Role in Aging and in the Treatment of Chronic Diseases - Neil Riordan, PA, PhD.

Published on May 16, 2019


Dr. Riordan discusses stem cell therapy at the Stem Cell Institute in Panama City, Panama. He mentions the two main types of adult stem cells but his talk focuses on mesenchymal stem cells including their sources and functions. Then he goes on to discuss specifically the specially selected human umbilical cord tissue-derived MSCs used in Panama. He highlights several clinical trials for spinal cord injury, rheumatoid arthritis, diabetes and cancer inhibition. He shows MSCs growing in culture and discusses 3D culturing. He then goes into cord tissue products being offered in the US including Signature Cord, which he developed. Finally, Dr. Riordan discusses current US law and the new stem cell law in Texas, including where he sees the industry in the US going from here.


http://www.cellmedicine.com

https://www.youtube.com/watch?v=f9O3Lyz8qw0

williatw
Posts: 1844
Joined: Mon Oct 12, 2009 7:15 pm
Location: Ohio

Re: Factor X have we finally found the fountain of Youth?

Postby williatw » Sun Aug 25, 2019 6:44 pm

More about Neil Riordan:

What I've Learned From Neil Riordan And Why I Still Go to Panama For Stem Cell Treatment





Published on Sep 2, 2018


Dr. Riordan is the founder of the Stem Cell Institute in Panama. His clinic was where I first went in October 2008 for treatment that I hoped would help the debilitation and immobility my progressive MS had caused. This man's revolutionary regenerative medical approach changed my life! iLoveMyNewStemCells because all that I have continued to learn during my own stem cell journey. Loved this interview and thought others may benefit from hearing more too ...


https://www.youtube.com/watch?v=73nGjpfqRdk

kurt9
Posts: 562
Joined: Mon Oct 15, 2007 4:14 pm
Location: Portland, Oregon, USA

Re: Factor X have we finally found the fountain of Youth?

Postby kurt9 » Mon Aug 26, 2019 3:46 pm

The best stem cell therapies are without the stem cells (e.g. cellular reprogramming). That's why its better to wait another 5 years, if possible, rather than doing stem cell treatments that may or may not work.

williatw
Posts: 1844
Joined: Mon Oct 12, 2009 7:15 pm
Location: Ohio

Re: Factor X have we finally found the fountain of Youth?

Postby williatw » Sat Sep 07, 2019 7:47 pm

Brent Nally interviews Dr. Aubrey de Grey @ SENS on July 17, 2019

Published on Jul 18, 2019


My mission is to drastically improve your life by helping you break bad habits, build and keep new healthy habits to make you the best version of yourself. I read the books and do all the research and share my findings with you!

This video is an interview of Dr. Aubrey de Grey @ SENS on July 17, 2019. My wife, Lauren Nally, was our camerawoman.



https://www.youtube.com/watch?v=TquJyz7tGfk

Rather long interview of Dr. Aubrey de Grey; rather interesting note, at about 13:30 minutes in the interviewer makes reference to the long awaited Bill Andrews' telomerase therapy's "patient zero". He (the interviewer) made reference to a conversation he had with Liz Parrish where she indicated said patient who is said to have late stage Alzheimer's, had finally received the telomerase therapy



ADDENDUM: In response to a posted question:

"Thanks for the interview Brent Nally. At about 13:30 you make reference to Bill Andrews' long awaited telomerase therapy patient. Any idea when Andrews will have something to say about progress/results of the treatments?"

Reply:


"I’ll be at RAADfest October 3-6th 2019 in Las Vegas with Dr. Aubrey de Grey, Dr. Bill Andrews, Liz Parrish and many other longevity experts. I’ll ask Bill & Liz for an update on the telomerase gene therapy patient who has Alzheimer’s. This private patient with Alzheimer’s was the second publicly known person (Liz was the first) to receive this telomerase gene therapy. Stay subscribed to my YouTube channel for this update."


In one of the previous interviews I recall Bill Andrews said himself that he didn't regard Liz Parrish's treatment (which he indicated that he was not directly associated with) to be as comprehensive as the one he was going to do on this patient.

williatw
Posts: 1844
Joined: Mon Oct 12, 2009 7:15 pm
Location: Ohio

Re: Factor X have we finally found the fountain of Youth?

Postby williatw » Sun Sep 08, 2019 10:41 am

NEWS · 05 September 2019


First hint that body’s ‘biological age’ can be reversed

In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’, which tracks a person’s biological age.


Image
A person’s biological age, measured by the epigenetic clock, can lag behind or exceed their chronological ageCredit: Patrick McDermott/Getty

A small clinical study in California has suggested for the first time that it might be possible to reverse the body’s epigenetic clock, which measures a person’s biological age.

For one year, nine healthy volunteers took a cocktail of three common drugs — growth hormone and two diabetes medications — and on average shed 2.5 years of their biological ages, measured by analysing marks on a person’s genomes. The participants’ immune systems also showed signs of rejuvenation.

The results were a surprise even to the trial organizers — but researchers caution that the findings are preliminary because the trial was small and did not include a control arm.

“I’d expected to see slowing down of the clock, but not a reversal,” says geneticist Steve Horvath at the University of California, Los Angeles, who conducted the epigenetic analysis. “That felt kind of futuristic.” The findings were published on 5 September in Aging Cell.

“It may be that there is an effect,” says cell biologist Wolfgang Wagner at the University of Aachen in Germany. “But the results are not rock solid because the study is very small and not well controlled.”

Marks of life

The epigenetic clock relies on the body’s epigenome, which comprises chemical modifications, such as methyl groups, that tag DNA. The pattern of these tags changes during the course of life, and tracks a person’s biological age, which can lag behind or exceed chronological age.

Scientists construct epigenetic clocks by selecting sets of DNA-methylation sites across the genome. In the past few years, Horvath — a pioneer in epigenetic-clock research — has developed some of the most accurate ones.

The latest trial was designed mainly to test whether growth hormone could be used safely in humans to restore tissue in the thymus gland. The gland, which is in the chest between the lungs and the breastbone, is crucial for efficient immune function. White blood cells are produced in bone marrow and then mature inside the thymus, where they become specialized T cells that help the body to fight infections and cancers. But the gland starts to shrink after puberty and increasingly becomes clogged with fat.

Evidence from animal and some human studies shows that growth hormone stimulates regeneration of the thymus. But this hormone can also promote diabetes, so the trial included two widely used anti-diabetic drugs, dehydroepiandrosterone (DHEA) and metformin, in the treatment cocktail.

The Thymus Regeneration, Immunorestoration and Insulin Mitigation (TRIIM) trial tested 9 white men between 51 and 65 years of age. It was led by immunologist Gregory Fahy, the chief scientific officer and co-founder of Intervene Immune in Los Angeles, and was approved by the US Food and Drug Administration in May 2015. It began a few months later at Stanford Medical Center in Palo Alto, California.

Fahy’s fascination with the thymus goes back to 1986, when he read a study in which scientists transplanted growth-hormone-secreting cells into rats, apparently rejuvenating their immune systems. He was surprised that no one seemed to have followed up on the result with a clinical trial. A decade later, at age 46, he treated himself for a month with growth hormone and DHEA, and found some regeneration of his own thymus.

In the TRIIM trial, the scientists took blood samples from participants during the treatment period. Tests showed that blood-cell count was rejuvenated in each of the participants. The researchers also used magnetic resonance imaging (MRI) to determine the composition of the thymus at the start and end of the study. They found that in seven participants, accumulated fat had been replaced with regenerated thymus tissue.

Rewinding the clock

Checking the effect of the drugs on the participants’ epigenetic clocks was an afterthought. The clinical study had finished when Fahy approached Horvath to conduct an analysis.

Horvath used four different epigenetic clocks to assess each patient’s biological age, and he found significant reversal for each trial participant in all of the tests. “This told me that the biological effect of the treatment was robust,” he says. What’s more, the effect persisted in the six participants who provided a final blood sample six months after stopping the trial, he says.

“Because we could follow the changes within each individual, and because the effect was so very strong in each of them, I am optimistic,” says Horvath.

Researchers are already testing metformin for its potential to protect against common age-related diseases, such as cancer and heart disease. Fahy says that the three drugs in the cocktail might contribute separately to the effect on biological ageing through unique mechanisms. Intervene Immune is planning a larger study that will include people of different age groups and ethnicities, and women.

Regenerating the thymus could be useful in people who have underactive immune systems, including older people, he says. Pneumonia and other infectious diseases are a major cause of death in people older than 70.

Cancer immunologist Sam Palmer at the Herriot-Watt University in Edinburgh says that it is exciting to see the expansion of immune cells in the blood. This “has huge implications not just for infectious disease but also for cancer and ageing in general”.



https://www.nature.com/articles/d41586-019-02638-w

kurt9
Posts: 562
Joined: Mon Oct 15, 2007 4:14 pm
Location: Portland, Oregon, USA

Re: Factor X have we finally found the fountain of Youth?

Postby kurt9 » Mon Sep 09, 2019 4:45 pm

I personally know the guy behind this (I've known him for 30 years). He did this because he came up with a way to regenerate his thymus gland. This is definitely useful work and we definitely need to regenerate our thymus glands. However, we need to regenerate our lymphatic system as well in order for that regenerated thymus gland to do its job. However, the fact that biological age (as measured by the Horvoth clock) was reversed is significant in its own right.


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